Fatty acid sensing is a research area focused on understanding how cells and organisms detect and respond to changes in levels of fatty acids in their environment. Fatty acids are key components of cell membranes and serve as energy sources, signaling molecules, and regulators of metabolism. The sensing of fatty acids by cells involves various receptors, transporters, and signaling pathways that regulate processes such as lipid metabolism, energy balance, inflammation, and insulin sensitivity. Understanding fatty acid sensing has important implications for the development of therapies for metabolic disorders, obesity, diabetes, and other health conditions.